منابع مشابه
Voltage-Gated Sodium Channels Modulation by Bothutous Schach Scorpion Venom
Buthotus schach is one of the dangers scorpion in Iran that belong to the Buthidae family. Toxins are existing in venom scorpion, modulate the ion channels by blocking or opening the pore of the channel or by altering the voltage gating and useful as pharmacological tools. In the present study, we investigated the effect of venom and its obtained fractions by gel filtrations on electrophysiolog...
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Antiepileptic drugs (AEDs) protect against seizures through interactions with a variety of cellular targets. By affecting the functional activity of these targets, AEDs suppress abnormal hypersynchronous activity in brain circuits, leading to protection against seizures. The actions on these targets can be categorized into four broad groups: (i) modulation of voltage-gated ion channels, includi...
متن کاملNoncanonical Roles of Voltage-Gated Sodium Channels
The Hodgkin-Huxley formulation, at its 60th anniversary, remains a bastion of neuroscience. Sodium channels Nav1.1-Nav1.3 and Nav1.6-Nav1.9 support electrogenesis in neurons and are often considered "neuronal," whereas Nav1.4 and Nav1.5 drive electrogenesis in skeletal and cardiac muscle. These channels are, however, expressed in cell types that are not considered electrically excitable. Here, ...
متن کاملNeurological perspectives on voltage-gated sodium channels
The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding th...
متن کاملNomenclature of Voltage-Gated Sodium Channels
been given different names, so that there are multiple Sodium Channels synonyms for many of sodium channel isoforms. To eliminate confusion resulting from the multiplicity of names, we propose a standardized nomenclature for Voltage-gated sodium channels are critical elements of voltage-gated sodium channels (Table 1). This nomen-action potential initiation and propagation in excitable clature ...
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ژورنال
عنوان ژورنال: Channels
سال: 2013
ISSN: 1933-6950,1933-6969
DOI: 10.4161/chan.24380